|First seen in:||Anatomy Park|
|Main voice actor:||Gary Anthony Williams|
- “Hey, Doc... I got news for ya! Your living museum is officially a wild safari!”
- —When Hepatitis A is spotted
He originally approaches Morty with disdain, but later compliments the boy's ability to think on his feet. It is later revealed that Poncho was responsible for the outbreak of diseases, when Morty discovers Poncho carrying around the Bubonic Plague.
Poncho reveals that he'd perform any job over working for Dr. Xenon Bloom, who gave him horrible employee benefits. When the safety of Annie is threatened, Morty throws himself at Poncho. The Bubonic plague then turns on Poncho, who falls from a high balcony.
- The tattoo on Poncho's right shoulder is an ode to the South African band Die Antwoord.