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Toxic Rick is the embodiment of all qualities Rick deems negative, created as the result of Rick and Morty having all their cognitive toxins removed in an intergalactic day spa. His only appearance was in "Rest and Ricklaxation".
Toxic Rick was aggressive, egotistical, dishonest, and vengeful, attempting to trick Detox Rick and Detox Morty into getting trapped in the toxic universe where they originally left their counterparts. Failing that, he reveled in his ability to decide the fate of the entire world by toxifying it out of spite. Rick's alcoholism is also shown to be funneled into Toxic Rick, as the latter had the bit of alcohol on his lip while Detox Rick didn't. Despite these qualities however, he was also passionate and protective of Toxic Morty, ultimately sacrificing his independence to save him.
Detox Rick implicitly described him as being entitled, narcissistic, lonely, and irrational (in his concern for his grandson). This means that regular Rick views these as negative qualities in himself; Rick is both critical of himself for his ego, but also for his attachments, like family.